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Literature summary extracted from

  • Stupans, I.; Kong, S.; Kirlich, S.; McKinnon, R.A.; Murray, M.
    Testosterone dehydrogenase activity in koala liver: characterization of cofactor and steroid substrate differences (2000), Comp. Biochem. Physiol. B, 125, 245-250.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.239 17beta-estradiol 0.175 mM, 25-40% inhibition of testosterone oxidation Phascolarctos cinereus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.239 0.0174
-
 testosterone enzyme avtivity in hepatic microsomes, one individual animal Phascolarctos cinereus
1.1.1.239 0.0181
-
 NAD+
-
 Rattus norvegicus
1.1.1.239 0.0181
-
 NAD+ enzyme activity in hepatic microsomes Phascolarctos cinereus
1.1.1.239 0.0185
-
 NAD+ enzyme avtivity in hepatic microsomes, one individual animal Phascolarctos cinereus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.239 microsome
-
 Homo sapiens
-
-
1.1.1.239 microsome
-
 Rattus norvegicus
-
-
1.1.1.239 microsome
-
 Phascolarctos cinereus
-
-
1.1.1.239 microsome
-
 Notamacropus eugenii
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.239 testosterone + NAD+ Homo sapiens
-
 androst-4-ene-3,17-dione + NADH + H+
-
 ?
1.1.1.239 testosterone + NAD+ Rattus norvegicus
-
 androst-4-ene-3,17-dione + NADH + H+
-
 ?
1.1.1.239 testosterone + NAD+ Phascolarctos cinereus
-
 androst-4-ene-3,17-dione + NADH + H+
-
 ?
1.1.1.239 testosterone + NAD+ Notamacropus eugenii
-
 androst-4-ene-3,17-dione + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.239 Homo sapiens
-
-
-
1.1.1.239 Notamacropus eugenii
-
 wallaby
-
1.1.1.239 Phascolarctos cinereus
-
 koala
-
1.1.1.239 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.239 liver
-
 Homo sapiens
-
1.1.1.239 liver
-
 Rattus norvegicus
-
1.1.1.239 liver
-
 Phascolarctos cinereus
-
1.1.1.239 liver
-
 Notamacropus eugenii
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.239 0.000176
-
 enzyme activity in hepatic cytosol Notamacropus eugenii
1.1.1.239 0.00035
-
 enzyme activity in hepatic cytosol Phascolarctos cinereus
1.1.1.239 0.00044
-
 enzyme activity in hepatic cytosol Homo sapiens
1.1.1.239 0.0007
-
 enzyme activity in hepatic microsomes Notamacropus eugenii
1.1.1.239 0.00168
-
 enzyme activity in hepatic microsomes Homo sapiens
1.1.1.239 0.00283
-
 enzyme activity in hepatic microsomes Phascolarctos cinereus
1.1.1.239 0.01794
-
 enzyme activity in hepatic microsomes Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.239 testosterone + NAD+
-
 Homo sapiens androst-4-ene-3,17-dione + NADH + H+
-
 ?
1.1.1.239 testosterone + NAD+
-
 Rattus norvegicus androst-4-ene-3,17-dione + NADH + H+
-
 ?
1.1.1.239 testosterone + NAD+
-
 Phascolarctos cinereus androst-4-ene-3,17-dione + NADH + H+
-
 ?
1.1.1.239 testosterone + NAD+
-
 Notamacropus eugenii androst-4-ene-3,17-dione + NADH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.239 NAD+
-
 Homo sapiens
1.1.1.239 NAD+
-
 Rattus norvegicus
1.1.1.239 NAD+
-
 Phascolarctos cinereus
1.1.1.239 NAD+
-
 Notamacropus eugenii